Acoramidis (AG10) | Transthyretin stabilizer | Probechem Biochemicals

Chemical Structure : Acoramidis

CAS No.: 1446711-81-4

加入收藏

Acoramidis (Transthyretin stabilizer AG10)

货号: PC-49857Not For Human Use, Lab Use Only.

Acoramidis (AG10) is a potent and selective kinetic stabilizer and ligand of transthyretin (TTR) ligand with apparent binding constant (Kapp) of 193 nM for WT-TTR.

规格	价格	库存
5 mg	￥2280	In stock
10 mg	￥3680	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Acoramidis (AG10) is a potent and selective kinetic stabilizer and ligand of transthyretin (TTR) ligand with apparent binding constant (Kapp) of 193 nM for WT-TTR.
AG10 binds TTR with negative cooperativity (Kd1 = 4.8 nM, Kd2 = 314 nM), V122I-TTR with Kd1 of 6.2 ± 2.0 nM and a Kd2 of 139 ± 80 nM.
AG10 is a highly effective and selective stabilizer of WT and V122I-TTR.
AG10 also prevents the dissociation of V122I-TTR in serum obtained from patients with FAC and protects human cardiomyocytes from TTR amyloid toxicity very effectively.
AG10 binds V122I-TTR with high affinity and to kinetically stabilize the tetramer, G10 is significantly better than tafamidis in inhibiting the amyloidogenesis of WT and V122I-TTR.
AG10 prevents dissociation of V122I-TTR in serum samples obtained from patients with familial amyloid cardiomyopathy.
AG10 stabilizes V122I- and WT-TTR equally well and also exceeds their efficacy to stabilize WT and mutant TTR in whole serum.

物理化学性质&存储条件

分子量	292.31
分子式	C15H17FN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid

参考文献

1. Sravan C Penchala, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7.

2. Sravan C Penchala , et al. Nat Chem Biol. 2015 Oct;11(10):793-8.

Acoramidis (Transthyretin stabilizer AG10)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Acoramidis (Transthyretin stabilizer AG10)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.