Ack1 inhibitor 37 |CAS:1026493-77-5 Probechem Biochemicals

Chemical Structure : Ack1 inhibitor 37

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Ack1 inhibitor 37

货号: PC-35147Not For Human Use, Lab Use Only.

Ack1 inhibitor 37 is a potent and selective Ack1 (TNK2) inhibitor with Ki of 0.3 nM, displays high selectivity over related kinases LCK, JAK3, KDR and TIE2 (Ki= 138, 6.5, 380 and 200 nM).

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生物&药学活性

Ack1 inhibitor 37 is a potent and selective Ack1 (TNK2) inhibitor with Ki of 0.3 nM, displays high selectivity over related kinases LCK, JAK3, KDR and TIE2 (Ki= 138, 6.5, 380 and 200 nM).
Ack1 inhibitor 37 demonstrates cell IC50 of 10 nM in cellular autophosphorylation assays, displays excellent ACK1 cellular inhibition, good kinase selectivity, and a suitable in vitro metabolic profile.

物理化学性质&存储条件

分子量	517.71
分子式	C28H31N5OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1,3-dithiolan-2-yl)methyl)-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

参考文献

1. Jiao X, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6212-7.

2. Mahajan K, et al. Cancer Lett. 2013 Sep 28;338(2):185-92.