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Acebilustat

Chemical Structure : Acebilustat

CAS No.: 943764-99-6

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Acebilustat (CTX-4430;EP-501)

货号: PC-45393Not For Human Use, Lab Use Only.

Acebilustat (CTX-4430, EP-501) is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 64 nM for inhibition of LTB4 production in human whole blood.

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25 mg ￥1880 In stock
50 mg ￥2980 In stock
100 mg ￥4880 In stock
200 mg Get quote
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Acebilustat (CTX-4430, EP-501) is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 64 nM for inhibition of LTB4 production in human whole blood.
Acebilustat (CTX-4430, EP-501) a new once‐daily oral antiinflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases.

物理化学性质&存储条件

分子量 481.5424
分子式 C29H27N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO; Methanol: ≥ 32 mg/mL
Chemical Name/SMILES

Benzoic acid, 4-[[(1S,4S)-5-[[4-[4-(2-oxazolyl)phenoxy]phenyl]methyl]-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]-

参考文献

1. Elborn JS, et al. Clin Transl Sci. 2017 Jan;10(1):20-27.

2. Elborn JS, et al. Clin Transl Sci. 2017 Jan;10(1):28-34.

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