Acalabrutinib (ACP-196) | BTK inhibitor | Probechem Biochemicals

Chemical Structure : Acalabrutinib

CAS No.: 1420477-60-6

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Acalabrutinib (ACP-196, APC196)

货号: PC-45383Not For Human Use, Lab Use Only.

Acalabrutinib (ACP-196) is a potent, irreversible, covalent second-generation BTK inhibitor with IC50 of 3 nM.

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10 mg	￥780	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

Acalabrutinib (ACP-196) is a potent, irreversible, covalent second-generation BTK inhibitor with IC50 of 3 nM.
Acalabrutinib (ACP-196) is more potent and selective than ibrutinib, and does not inhibit EGFR, Itk or Txk.
Acalabrutinib (ACP-196) inhibits tyrosine phosphorylation of downstream targets of ERK, IKB, and AKT, in the in vitro signaling assay on primary human CLL cells.
Acalabrutinib (ACP-196) inhibits anti-IgM-induced CD86 expression in CD19+ splenocytes with an ED50 of 0.34 mg/kg in mice.
Acalabrutinib (ACP-196) has promising safety and efficacy profiles for CLL treatment; orally active.

物理化学性质&存储条件

分子量	465.5065
分子式	C26H23N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Benzamide, 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-

参考文献

1. Byrd JC, et al. N Engl J Med. 2016 Jan 28;374(4):323-32.

2. Herman SEM, et al. Clin Cancer Res. 2017 Jul 15;23(14):3734-3743.

3. Niemann CU, et al. Clin Cancer Res. 2017 Jun 23. pii: clincanres.0650.2017.

Acalabrutinib (ACP-196, APC196)

生物&药学活性

物理化学性质&存储条件

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Acalabrutinib (ACP-196, APC196)

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