Ac-LESD-AMC | Caspase-8 substrate | Probechem Biochemicals

Chemical Structure : Ac-LESD-AMC

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Ac-LESD-AMC (N-acetyl-Leu-Glu-Ser-Asp-aminomethylcoumarin)

货号: PC-27874Not For Human Use, Lab Use Only.

Ac-LESD-AMC is a caspase-8 fluorogenic substrate (relative Kcat/K M = 0.15) that most efficiently hydrolyzed by caspase-8 and caspase-10, 10-fold faster than inflammatory caspases-1, -4, and -5.

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生物&药学活性

Ac-LESD-AMC is a caspase-8 fluorogenic substrate (relative Kcat/K M = 0.15) that most efficiently hydrolyzed by caspase-8 and caspase-10, 10-fold faster than inflammatory caspases-1, -4, and -5.

物理化学性质&存储条件

分子量	661.67
分子式	C30H39N5O12
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4S,7S,10S,13S)-7-(2-carboxyethyl)-10-(hydroxymethyl)-4-isobutyl-13-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid

参考文献

1. Bourne CM, et al. ACS Bio Med Chem Au. 2025 Jul 2;5(4):565-581.

Ac-LESD-AMC (N-acetyl-Leu-Glu-Ser-Asp-aminomethylcoumarin)

生物&药学活性

物理化学性质&存储条件

参考文献

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Ac-LESD-AMC (N-acetyl-Leu-Glu-Ser-Asp-aminomethylcoumarin)

生物&药学活性

物理化学性质&存储条件

参考文献

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