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首页-小分子抑制剂&激动剂-GPCR-GPR55-Abn-CBD
Abn-CBD

Chemical Structure : Abn-CBD

CAS No.: 22972-55-0

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Abn-CBD (Abnormal Cannabidiol)

货号: PC-35025Not For Human Use, Lab Use Only.

Abn-CBD (Abnormal Cannabidiol) is a selective agonist of GPR55 receptor with EC50 of 2.5 uM, shows no significant activity against CB1 and CB2 receptors (EC50>30 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Abn-CBD (Abnormal Cannabidiol) is a selective agonist of GPR55 receptor with EC50 of 2.5 uM, shows no significant activity against CB1 and CB2 receptors (EC50>30 uM).
    Abn-CBD is also a full agonist at GPR18, with EC50 of 0.835 uM for inducing p44/42 MAPK phosphorylation in HEK293 cells stably transfected with GPR18.
    Abn-CBD regulates the migratory activity of murine BV-2 microglial cells with EC50 of 0.6 uM.
    Abn-CBD induces endothelium-dependent vasodilation via a CB1/CB2/NO-independent mechanism and inhibits vasoconstriction induced by ET-1 in retinal arterioles.
    Abn-CBD also is a nonretinoid inhibitor of cellular retinol-binding protein 1 (CRBP1) with Ki of 67 nM.

    物理化学性质&存储条件

    分子量 314.469
    分子式 C21H30O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol

    参考文献

    1. Ryberg E, et al. Br J Pharmacol. 2007 Dec;152(7):1092-101.

    2. Walter L, et al. J Neurosci. 2003 Feb 15;23(4):1398-405.

    3. Alexander SP. Br J Pharmacol. 2012 Apr;165(8):2411-3.

    4. Járai Z, et al. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14136-41.

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