Abn-CBD (Abnormal Cannabidiol)

Chemical Structure : Abn-CBD

CAS No.: 22972-55-0

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货号: PC-35025Not For Human Use, Lab Use Only.

Abn-CBD (Abnormal Cannabidiol) is a selective agonist of GPR55 receptor with EC50 of 2.5 uM, shows no significant activity against CB1 and CB2 receptors (EC50>30 uM).

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Abn-CBD (Abnormal Cannabidiol) is a selective agonist of GPR55 receptor with EC50 of 2.5 uM, shows no significant activity against CB1 and CB2 receptors (EC50>30 uM).
Abn-CBD is also a full agonist at GPR18, with EC50 of 0.835 uM for inducing p44/42 MAPK phosphorylation in HEK293 cells stably transfected with GPR18.
Abn-CBD regulates the migratory activity of murine BV-2 microglial cells with EC50 of 0.6 uM.
Abn-CBD induces endothelium-dependent vasodilation via a CB1/CB2/NO-independent mechanism and inhibits vasoconstriction induced by ET-1 in retinal arterioles.
Abn-CBD also is a nonretinoid inhibitor of cellular retinol-binding protein 1 (CRBP1) with Ki of 67 nM.

物理化学性质&存储条件

分子量	314.469
分子式	C21H30O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol

参考文献

1. Ryberg E, et al. Br J Pharmacol. 2007 Dec;152(7):1092-101.

2. Walter L, et al. J Neurosci. 2003 Feb 15;23(4):1398-405.

3. Alexander SP. Br J Pharmacol. 2012 Apr;165(8):2411-3.

4. Járai Z, et al. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14136-41.