Abiraterone (CB-7598) | CYP17A1 inhibitor | Probechem Biochemicals

Chemical Structure : Abiraterone

CAS No.: 154229-19-3

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Abiraterone (CB-7598, CB7598)

货号: PC-45937Not For Human Use, Lab Use Only.

Abiraterone (CB-7598) is a potent and irreversible CYP17A1 inhibitor with IC50 of 4 nM for 17α-hydroxylase.

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25 mg	￥780	In stock
50 mg	￥1180	In stock
100 mg	￥1880	In stock
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生物&药学活性

Abiraterone (CB-7598) is a potent and irreversible CYP17A1 inhibitor with IC50 of 4 nM for 17α-hydroxylase.
Abiraterone shows 6-fold more selective for inhibition of 17α-hydroxylase over 17,20-lyase.
Abiraterone also acts as a partial antagonist of the AR, and as an inhibitor of the 3β-HSD, CYP11B1, and other CYP450s (e.g., CYP1A2, CYP2C9, and CYP3A4).
Abiraterone is highly active in the treatment of castration-resistant prostate cancer; the active agent of prodrug abiraterone acetate.

物理化学性质&存储条件

分子量	349.509
分子式	C24H31NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: < 1 mg/mL; H2O: < 1 mg/mL
Chemical Name/SMILES	Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, (3.beta.)-

参考文献

1. Jarman M, et al. J Med Chem. 1998 Dec 31;41(27):5375-81.

2. O'Donnell A, et al. Br J Cancer. 2004 Jun 14;90(12):2317-25.

3. Attard G, et al. J Clin Oncol. 2009 Aug 10;27(23):3742-8.

Abiraterone (CB-7598, CB7598)

生物&药学活性

物理化学性质&存储条件

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Abiraterone (CB-7598, CB7598)

生物&药学活性

物理化学性质&存储条件

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