RGX-104 (Abequolixron) | LXR agonist | Probechem Biochemicals

Chemical Structure : Abequolixron

CAS No.: 610318-54-2

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Abequolixron (RGX-104)

货号: PC-38644Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg	￥4780	In stock
100 mg		Get quote

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生物&药学活性

RGX-104 (Abequolixron) is a small-molecule liver X receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the apolipoprotein E (ApoE) gene, enhances anti-tumor immune responses and inhibits proliferation of tumor cells.
RGX-104 (Abequolixron) activates the innate immune system, resulting in depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumor cells and endothelial cells in the tumor microenvironment.
RGX-104 (Abequolixron) selectively targets and binds to LXRbeta (NR1H2), thereby activating LXRbeta-mediated signaling, leading to the transcription of certain tumor suppressor genes and the downregulation of certain tumor promoter genes.

物理化学性质&存储条件

分子量	596.087
分子式	C34H33ClF3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-3-methylpropoxy]phenyl]acetic acid

参考文献

1. Liang H, et al. Biochem Biophys Res Commun. 2020 Jul 23;528(2):330-335.

2. Emerson Lim, et al. Cancer Res (2020) 80 (16_Supplement): CT146.

Abequolixron (RGX-104)

生物&药学活性

物理化学性质&存储条件

参考文献

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Abequolixron (RGX-104)

生物&药学活性

物理化学性质&存储条件

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