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首页-抗体和重组蛋白-Biosimilar Antibody-Abciximab
Abciximab

Chemical Structure : Abciximab

CAS No.: 143653-53-6

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Abciximab (Anti-human GPIIb/IIIa mAb, human IgG1 Fab-Kappa; c7E3 Fab)

货号: PC-Ab1095Not For Human Use, Lab Use Only.

Abciximab (Abcixifiban.

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Abciximab (Abcixifiban; c7E3 Fab) is a monoclonal anti-glycoprotein IIb/IIIa receptor antibody antagonist, prevents platelet aggregation by blocking glycoprotein IIb/IIIa receptors on their platelet's plasma membrane and inhibits fibrinogen binding. It exerts it`s action by steric hindrance of the receptor itself and prevents platelet aggregation and subsequent thrombus formation and blocking interaction of fibrinogen. It also inhibits vitronectin receptor which mediates both platelet coagulation as well as endothelial and vascular smooth muscle proliferation.

物理化学性质&存储条件

分子量
分子式 Human IgG1 Fab-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Abciximab; Reopro; Abcixifiban;143653-53-6; c7E3 Fab; Anti-human Glycoprotein IIb/IIIa; Anti-human GP IIb/IIIa; Anti-human glycoprotein receptor

参考文献

1. 1, Faulds D, et al. Drugs. 1994 Oct;48(4):583-98. 2, Kereiakes DJ, et al. Am J Cardiol. 1996 Nov 15;78(10):1161-3. 3, Kereiakes DJ, et al. Circulation. 1996 Sep 1;94(5):906-10. 4, Le Breton H, et al. J Am Coll Cardiol. 1996 Dec;28(7):1643-51.

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