AZSMO-23 |CAS:496793-75-0 Probechem Biochemicals

Chemical Structure : AZSMO-23

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AZSMO-23 (AZSMO 23;AZSMO23)

货号: PC-60836Not For Human Use, Lab Use Only.

AZSMO-23 (AZSMO 23, AZSMO23) is a potent hERG potassium channel (Kv11.1) activator that activates WT hERG pre-pulse and tail current with EC50 of 28.6 and 11.2 μM respectively.

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生物&药学活性

AZSMO-23 (AZSMO 23, AZSMO23) is a potent hERG potassium channel (Kv11.1) activator that activates WT hERG pre-pulse and tail current with EC50 of 28.6 and 11.2 μM respectively.
AZSMO-23 increases pre-pulse current at +40 mV by 952% and tail current at −30 mV by 238% at 100 uM.
AZSMO-23 blocks the mutant channel hERG Y652A, but shows enhanced activator activity against another mutant channel hERG F656T.
AZSMO-23 also blocks hKv4.3-hKChIP2.2, hCav3.2 and hKv1.5 and activated hCav1.2/β2/α2δ channels.

物理化学性质&存储条件

分子量	348.79
分子式	C19H13ClN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[3-(1H-benzimidazol-2-yl)-4-chloro-phenyl]pyridine-3-carboxamide

参考文献

1. Mannikko R, et al. Br J Pharmacol. 2015 Jun;172(12):3112-25.

AZSMO-23 (AZSMO 23;AZSMO23)

生物&药学活性

物理化学性质&存储条件

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AZSMO-23 (AZSMO 23;AZSMO23)

生物&药学活性

物理化学性质&存储条件

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