AZ Dyrk1B 33 | DYRK inhibitor | Probechem Biochemicals

Chemical Structure : AZ Dyrk1B 33

CAS No.: 1679330-37-0

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AZ Dyrk1B 33 (AZ-Dyrk1B-33)

货号: PC-49263Not For Human Use, Lab Use Only.

AZ Dyrk1B 33 is a potent dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with IC50 of 16.8/39/254/430 nM for DYRK1A/1B/2/3, respectively, does not inhibit DYRK4 (IC50>30 uM).

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AZ Dyrk1B 33 is a potent dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with IC50 of 16.8/39/254/430 nM for DYRK1A/1B/2/3, respectively, does not inhibit DYRK4 (IC50>30 uM).
AZ Dyrk1B 33 decreased glucose levels in both larval and juvenile fish, recapitulated the effect on Tg(gip:nLuc) zebrafish at a lower concentration, also increased the number of K- and L-cells, did not change the number of beta-cells.
AZ Dyrk1B 33 promoted enteroendocrine cell differentiation through Nfatc4.
AZ Dyrk1B 33 (10 mg/kg, oral gavage) increases the prevalence of incretin+ cells and improved glucose control in diabetic mice.

物理化学性质&存储条件

分子量	300.365
分子式	C19H16N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzyl-3-(2-methylpyrimidin-4-yl)-1H-pyrrolo[2,3-c]pyridine

参考文献

1. Lianhe Chu, et al. Cell Chem Biol. 2022 Aug 17;S2451-9456(22)00277-X.

AZ Dyrk1B 33 (AZ-Dyrk1B-33)

生物&药学活性

物理化学性质&存储条件

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AZ Dyrk1B 33 (AZ-Dyrk1B-33)

生物&药学活性

物理化学性质&存储条件

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