AZD 9977 |CAS:1850385-64-6 Probechem Biochemicals

Chemical Structure : AZD9977

CAS No.: 1850385-64-6

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AZD9977 (Balcinrenone, AZD-9977)

货号: PC-62592Not For Human Use, Lab Use Only.

Balcinrenone (AZD9977) is a novel, first-in-class, selective and oral mineralocorticoid receptor (MR) modulator with pKi of 7.5, shows little to no affitnity for GR, PR and AR (pIC50<5.5).

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5 mg	￥1480	In stock
10 mg	￥2280	In stock
25 mg	￥3780	In stock
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100 mg		Get quote

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生物&药学活性

Balcinrenone (AZD9977) is a novel, first-in-class, selective and oral mineralocorticoid receptor (MR) modulator with pKi of 7.5, shows little to no affitnity for GR, PR and AR (pIC50<5.5).
Balcinrenone (AZD9977) dose dependently reduces albuminuria and improves kidney histopathology similar to eplerenone in db/db uni-nephrectomised mice and uni-nephrectomised rats, does not affect urinary Na+/K+ ratio.

物理化学性质&存储条件

分子量	399.378
分子式	C20H18FN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(7-fluoro-4-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)-N-methylacetamide

参考文献

1. Bamberg K, et al. PLoS One. 2018 Feb 23;13(2):e0193380.

2. Erlandsson F, et al. Br J Clin Pharmacol. 2018 Feb 21. doi: 10.1111/bcp.13562.

AZD9977 (Balcinrenone, AZD-9977)

生物&药学活性

物理化学性质&存储条件

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AZD9977 (Balcinrenone, AZD-9977)

生物&药学活性

物理化学性质&存储条件

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