AZD9496 |CAS:1639042-08-2 Probechem Biochemicals

Chemical Structure : AZD9496

CAS No.: 1639042-08-2

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AZD9496 (AZD-9496)

货号: PC-43270Not For Human Use, Lab Use Only.

AZD9496 is a potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AZD9496 is a potent, selective estrogen receptor downregulator (SERD) with ER downregulation pIC50 of 9.68.
AZD9496 shows pM equipotent binding to both ERα and ERβ isoforms, highly selective binding compared with progesterone (∼650-fold), glucocorticoid (∼11,223-fold), and androgen (∼36,375-fold) receptor LBDs.
AZD9496 downregulator of ERα in vitro and in vivo in ER-positive models of breast cancer and is orally available.

物理化学性质&存储条件

分子量	442.4734
分子式	C25H25F3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 104.5 mg/mL
Chemical Name/SMILES	2-Propenoic acid, 3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-, (2E)-

参考文献

1. De Savi C, et al. J Med Chem. 2015 Oct 22;58(20):8128-40.

2. Weir HM, et al. Cancer Res. 2016 Jun 1;76(11):3307-18.

3. Toy W, et al. Cancer Discov. 2017 Mar;7(3):277-287.

AZD9496 (AZD-9496)

生物&药学活性

物理化学性质&存储条件

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AZD9496 (AZD-9496)

生物&药学活性

物理化学性质&存储条件

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