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首页-小分子抑制剂&激动剂-GPCR-mGluR-AZD9272
AZD9272

Chemical Structure : AZD9272

CAS No.: 327056-26-8

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AZD9272 (AZD-9272)

货号: PC-60792Not For Human Use, Lab Use Only.

AZD9272 is a potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM

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5 mg ￥1280 In stock
10 mg ￥1880 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD9272 is a potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM.
AZD9272 does not elicit any agonist, antagonist or positive allosteric modulator on any of the other seven mGluR subtypes at 30 uM.
AZD9272 completely reverses the glutamate-stimulated phosphatidyl inositol hydrolysis in human mGluR5-GHEK cells with IC50 of 26 nM.
AZD9272 causes psychoactive effects selectively mediated by mGluR5 mechanisms in vivo,

物理化学性质&存储条件

分子量 284.226
分子式 C14H6F2N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-fluoro-5-(3-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

参考文献

1. Raboisson P, et al. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6974-9.

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