AZD8330 (ARRY-424704, ARRY-704) | MEK1/2 inhibitor | Probechem Biochemicals

Chemical Structure : AZD8330

CAS No.: 869357-68-6

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AZD8330 (ARRY-424704, ARRY-704, AZD-8330)

货号: PC-42872Not For Human Use, Lab Use Only.

AZD8330 (ARRY-424704, ARRY-704) is a potent, selective, non-ATP competitive MEK1/2 inhibitor with IC50 of 7 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

AZD8330 (ARRY-424704, ARRY-704) is a potent, selective, non-ATP competitive MEK1/2 inhibitor with IC50 of 7 nM.
AZD8330 displays no inhibitory activity against a panel of >200 other kinases.
AZD8330 demonstrates sub-nanomolar potency in mechanistic (pERK) and low to sub-nanomolar potency in functional (proliferation) assays in MEK1/2 inhibitor sensitive cell lines.
AZD8330 inhibits ERK phosphorylation and causes tumor growth inhibition in Calu-6 rat xenograft.

物理化学性质&存储条件

分子量	461.2267
分子式	C16H17FIN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Pyridinecarboxamide, 2-[(2-fluoro-4-iodophenyl)amino]-1,6-dihydro-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-

参考文献

1. Cohen RB, et al. Eur J Cancer. 2013 May;49(7):1521-9.

2. Baranski Z, et al. Genes Cancer. 2015 Nov;6(11-12):503-12.

AZD8330 (ARRY-424704, ARRY-704, AZD-8330)

生物&药学活性

物理化学性质&存储条件

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AZD8330 (ARRY-424704, ARRY-704, AZD-8330)

生物&药学活性

物理化学性质&存储条件

参考文献

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