AZD8186 |CAS:1627494-13-6 Probechem Biochemicals

Chemical Structure : AZD8186

CAS No.: 1627494-13-6

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AZD8186 (AZD-8186)

货号: PC-42978Not For Human Use, Lab Use Only.

AZD8186 is a potent, isoform-specific PI3Kβ inhibitor with IC50 of 4 nM, also inhibits PI3Kδ (IC50=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM).

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

AZD8186 is a potent, isoform-specific PI3Kβ inhibitor with IC50 of 4 nM, also inhibits PI3Kδ (IC50=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM).
AZD8186 inhibits ADP-induced human platelet aggregation with IC50 of 186 nM, shows no significant binding to 442 other kinases.
AZD8186 inhibits PI3Kβ-dependent activation of pAKT (Ser473) in MDA-MB-468 cells (IC50=3 nM), inhibits proliferation of MDA-MB-468 cells (GI50=65 nM).
AZD8186 suppresses phosphorylation of AKT, PRAS40, S6, and FOXO with IC50 of <10-300 nM in breast cancer cells, also induces nuclear translocation of FOXO3a in vitro.
AZD8186 effectively inhibits growth of prostate and TNBC tumors, both as a single agent and in combination with docetaxel.

物理化学性质&存储条件

分子量	457.4698
分子式	C24H25F2N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 35 mg/mL
Chemical Name/SMILES	4H-1-Benzopyran-6-carboxamide, 8-[(1R)-1-[(3,5-difluorophenyl)amino]ethyl]-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-

参考文献

1. Hancox U, et al. Mol Cancer Ther. 2015 Jan;14(1):48-58.

2. Barlaam B, et al. J Med Chem. 2015 Jan 22;58(2):943-62.

3. Schwartz S, et al. Cancer Cell. 2015 Jan 12;27(1):109-22.

4. Lynch JT, et al. Clin Cancer Res. 2017 Dec 15;23(24):7584-7595.

AZD8186 (AZD-8186)

生物&药学活性

物理化学性质&存储条件

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AZD8186 (AZD-8186)

生物&药学活性

物理化学性质&存储条件

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