Brensocatib (AZD7986) | CatC inhibitor | ProbeChem Biochemicals

Chemical Structure : AZD7986

CAS No.: 1802148-05-5

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AZD7986 (Brensocatib, INS-1007, AZD-7986, INS1007)

货号: PC-60297Not For Human Use, Lab Use Only.

AZD7986 (INS-1007, Brensocatib) is a highly potent, reversible, and selective DPP1 (cathepsin C, CatC) inhibitor with enzyme and cell pIC50 of 8.4.

规格	价格	库存
5 mg	￥1480	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
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100 mg		Get quote

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生物&药学活性

AZD7986 (INS-1007, Brensocatib) is a highly potent, reversible, and selective DPP1 (cathepsin C, CatC) inhibitor with enzyme and cell pIC50 of 8.4.
AZD7986 (INS-1007, Brensocatib) shows excellent selectivity over other cathepsins, including cathepsins S, L, B, K, D, E, Z, H, and G.
AZD7986 (INS-1007, Brensocatib) inhibits activation of all three NSPs (NE, Pr3, and CatG) with pIC50 of 7 in human primary bone marrow-derived CD34+ neutrophil progenitor cells.
AZD7986 (INS-1007, Brensocatib) exhibits suitable human PK properties and is a clinical candidate for COPD.

物理化学性质&存储条件

分子量	420.469
分子式	C23H24N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide

参考文献

1. Doyle K, et al. J Med Chem. 2016 Oct 27;59(20):9457-9472.

AZD7986 (Brensocatib, INS-1007, AZD-7986, INS1007)

生物&药学活性

物理化学性质&存储条件

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AZD7986 (Brensocatib, INS-1007, AZD-7986, INS1007)

生物&药学活性

物理化学性质&存储条件

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