AZD7687 | DGAT1 inhibitor | Probechem Biochemicals

Chemical Structure : AZD7687

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AZD7687 (AZD 7687, AZD-7687)

货号: PC-20386Not For Human Use, Lab Use Only.

AZD7687 (AZD-7687) is a potent, selective DGAT1 inhibitor with IC50 of 80 nM (hDGAT1), >400-fold selectivity over hACAT1.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

AZD7687 (AZD-7687) is a potent, selective DGAT1 inhibitor with IC50 of 80 nM (hDGAT1), >400-fold selectivity over hACAT1.
AZD7687 potently inhibits human DGAT1 liver microsome with IC50 of 70 nM, and higher inhibitory potency against human adipose tissue with IC50 of 10 nM.
AZD7687 only shows little to no inhibition of ACAT (79% at 10 μM), FAAH (IC50 = 3.7 μM), muscarinic M2 receptor (IC50 = 80.5 μM), and PDE10A1 in a panel of 339 in vitro radioligand binding and enzyme assays.

物理化学性质&存储条件

分子量	367.45
分子式	C21H25N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	{trans-4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl] cyclohexyl}acetic Acid

参考文献

1. Barlind JG, et al. J Med Chem. 2012 Dec 13;55(23):10610-29.

AZD7687 (AZD 7687, AZD-7687)

生物&药学活性

物理化学性质&存储条件

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AZD7687 (AZD 7687, AZD-7687)

生物&药学活性

物理化学性质&存储条件

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