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首页-小分子抑制剂&激动剂-Tyrosine Kinase-c-Fms (CSF1R)-AZD7507
AZD7507

Chemical Structure : AZD7507

CAS No.: 1041852-85-0

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AZD7507 (AZD-7507;AZD 7507)

货号: PC-35232Not For Human Use, Lab Use Only.

AZD7507 (AZD-7507) is a potent, selective, orally available CSF-1R (c-FMS) with IC50 of 32 nM.

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5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥3980 In stock
50 mg ￥5980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD7507 (AZD-7507) is a potent, selective, orally available CSF-1R (c-FMS) with IC50 of 32 nM.
AZD7507 demonstrates cleaner secondary pharmacology profiles, demonstrates good rat oral PK, with in vivo clearance of 7 ml/min/kg and 42% bioavailability.
AZD7507 has an IC50 >20 uM in the canine L-type Ca channel assays.
AZD7507 causes shrinkage of established tumors and increases mouse survival in genetic PDAC model.

物理化学性质&存储条件

分子量 454.506
分子式 C23H27FN6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide

参考文献

1. Scott DA, et al. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6.

2. Boulter L, et al. J Clin Invest. 2015 Mar 2;125(3):1269-85.

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