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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ATM/ATR-AZD6738
AZD6738

Chemical Structure : AZD6738

CAS No.: 1352226-88-0

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AZD6738 (Ceralasertib, AZD-6738)

货号: PC-45607Not For Human Use, Lab Use Only.

AZD6738 (Ceralasertib) is a potent and selective inhibitor of ATR with IC50 of 1 nM.

规格 价格 库存 数量
5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg ￥5580 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD6738 (Ceralasertib) is a potent and selective inhibitor of ATR with IC50 of 1 nM.
AZD6738 (Ceralasertib) shows no significant activity for ATM, DNA-PK and mTOR.
AZD6738 (Ceralasertib) inhibits ATR kinase-dependent CHK1 phosphorylation in cells (IC50=74 nM).
AZD6738 (Ceralasertib) enhances the therapeutic efficacy of cisplatin in xenograft models。
AZD6738 (Ceralasertib) is orally active and bioavailable.

物理化学性质&存储条件

分子量 412.5085
分子式 C20H24N6O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 38 mg/mL
Chemical Name/SMILES

1H-Pyrrolo[2,3-b]pyridine, 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-

参考文献

1. Vendetti FP, et al. Oncotarget. 2015 Dec 29;6(42):44289-305.

2. Kwok M, et al. Blood. 2016 Feb 4;127(5):582-95.

3. Min A, et al. Mol Cancer Ther. 2017 Apr;16(4):566-577.

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