AZD6482 |CAS:1173900-33-8 Probechem Biochemicals

Chemical Structure : AZD6482

CAS No.: 1173900-33-8

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AZD6482 (AZD 6482;AZD-6482;KIN-193;KIN 193;KIN193)

货号: PC-42544Not For Human Use, Lab Use Only.

AZD6482 (KIN193) is a potent, selective and ATP competitive PI3Kβ inhibitor with IC50 of 10 nM.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

AZD6482 (KIN193) is a potent, selective and ATP competitive PI3Kβ inhibitor with IC50 of 10 nM.
AZD6482 (KIN193) dispalys weak activity over PI3Kδ/PI3Kα/PI3Kγ/DNA-PK (IC50=80/870/1090/420 nM).
AZD6482 (KIN193) potently inhibits Akt(Ser 473) phosphorylation in adenocarcinoma MDA-MB-468 cells (IC50=40 nM).
AZD6482 (KIN193) inhibits insulin-induced human adipocyte glucose uptake in vitro (IC50=4.4 uM).

物理化学性质&存储条件

分子量	408.4503
分子式	C22H24N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzoic acid, 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]-

参考文献

1. Giordanetto F, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3936-43.

2. Nylander S, et al. J Thromb Haemost. 2012 Oct;10(10):2127-36.

3. Laurent PA, et al. Blood. 2015 Jan 29;125(5):881-8.

AZD6482 (AZD 6482;AZD-6482;KIN-193;KIN 193;KIN193)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZD6482 (AZD 6482;AZD-6482;KIN-193;KIN 193;KIN193)

生物&药学活性

物理化学性质&存储条件

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