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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-GABA Receptor-AZD6280
AZD6280

Chemical Structure : AZD6280

CAS No.: 942436-93-3

AZD6280 (AZD-6280)

货号: PC-62765Not For Human Use, Lab Use Only.

AZD6280 is a potent, α2/3 functionally selective, partial GABAA receptor modulator with pKi of 7.7.

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2 mg ¥2880 In stock
5 mg ¥4780 In stock
10 mg ¥7580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD6280 is a potent, α2/3 functionally selective, partial GABAA receptor modulator with pKi of 7.7.
AZD6280 exerts neutral antagonism at the α1-subunit and partial efficacy at the α2,3-subunits over the α5-subunit.
AZD6280 shows potential for the treatment of anxiety disorders.

物理化学性质&存储条件

分子量 366.421
分子式 C20H22N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-amino-8-(2,5-dimethoxyphenyl)-N-propyl-3-cinnolinecarboxamide

参考文献

1. Jucaite A, et al. Psychopharmacology (Berl). 2017 Feb;234(4):707-716.

2. Chen X, et al. J Clin Psychopharmacol. 2015 Feb;35(1):22-33.

3. Te Beek ET, et al. Clin Pharmacol Drug Dev. 2015 Mar;4(2):149-54.

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