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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-AZD 5597
AZD 5597

Chemical Structure : AZD 5597

CAS No.: 924641-59-8

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AZD 5597 (AZD5597;AZD-5597)

货号: PC-61143Not For Human Use, Lab Use Only.

AZD 5597 is a highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2.

规格 价格 库存 数量
2 mg ￥2580 In stock
5 mg ￥3980 In stock
10 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD 5597 is a highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2.
AZD 5597 exhibits anti-proliferative activity against LoVo cells with IC50 of 39 nM, demonstrates anticancer activity in SW620 tumour xenograft, possesses suitable physiochemical and pharmacokinetic profiles for intravenous (i.v.) dosing.

物理化学性质&存储条件

分子量 437.513
分子式 C23H28FN7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-(4-((5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone

参考文献

1. Jones CD, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6369-73.

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