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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-AZD5305
AZD5305

Chemical Structure : AZD5305

CAS No.: 2589531-76-8

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AZD5305 (Saruparib, AZD-5305)

货号: PC-72405Not For Human Use, Lab Use Only.

Saruparib (AZD5305) is a potent, selective, orally active PARP1 inhibitor (IC50=3 nM) and PARP1-DNA trapper.

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10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Saruparib (AZD5305) is a potent, selective, orally active PARP1 inhibitor (IC50=3 nM) and PARP1-DNA trapper.
AZD5305 is highly selective for PARP1 over other PARP family members (PARP2 IC50=1.4 uM), with good secondary pharmacology and physicochemical properties and excellent pharmacokinetics in preclinical species.
AZD5305 reduced effects on human bone marrow progenitor cells in vitro, showed excellent in vivo efficacy in a BRCA mutant HBCx-17 PDX model.

物理化学性质&存储条件

分子量 406.49
分子式 C22H26N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(4-((7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)piperazin-1-yl)-N-methylpicolinamide

参考文献

1. Jeffrey W Johannes, et al. J Med Chem. 2021 Oct 14;64(19):14498-14512.

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