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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-AZD5153
AZD5153

Chemical Structure : AZD5153

CAS No.: 1869912-39-9

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AZD5153 (AZD-5153)

货号: PC-62986Not For Human Use, Lab Use Only.

AZD5153 is a potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD5153 is a potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM.
AZD5153 simultaneously binds to two bromodomains in BRD4; exhibits antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma.

物理化学性质&存储条件

分子量 479.585
分子式 C25H33N7O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-4-(2-(4-(1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)-1,3-dimethylpiperazin-2-one

参考文献

1. Bradbury RH, et al. J Med Chem. 2016 Sep 8;59(17):7801-17.

2. Rhyasen GW, et al. Mol Cancer Ther. 2016 Nov;15(11):2563-2574.

3. Collins TA, et al. CPT Pharmacometrics Syst Pharmacol. 2017 Jun;6(6):357-364.

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