AZD4635 |CAS:1321514-06-0 Probechem Biochemicals

Chemical Structure : AZD4635

CAS No.: 1321514-06-0

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AZD4635 (Imaradenant, HTL 1071, AZD-4635)

货号: PC-63144Not For Human Use, Lab Use Only.

AZD4635 (Imaradenant, HTL 1071) is a potent, selective and orally available adenosine 2A receptor (A2AR) inhibitor with Ki of 1.7 nM, > 30-fold selectivity over other adenosine receptors.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

AZD4635 (Imaradenant, HTL 1071) is a potent, selective and orally available adenosine 2A receptor (A2AR) inhibitor with Ki of 1.7 nM, > 30-fold selectivity over other adenosine receptors.
AZD4635 (Imaradenant, HTL 1071) reverses the inhibitory effects of different concentrations of adenosine in CHO cells stably expressing human A2AR with IC50 of 0.1 nM (incubated with 0.1 uM adenosine).
AZD4635 (Imaradenant, HTL 1071) reverses suppression and restores IFNγ secretion in cells incubated with NECA in ex vivo CD8+ T cell assay.
AZD4635 (Imaradenant, HTL 1071) reduces tumor burden and enhances antitumor immunity in vivo.

物理化学性质&存储条件

分子量	315.736
分子式	C15H11ClFN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine

参考文献

1. Alexandra Borodovsky, et al. AACR. DOI: 10.1158/1538-7445.

AZD4635 (Imaradenant, HTL 1071, AZD-4635)

生物&药学活性

物理化学性质&存储条件

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AZD4635 (Imaradenant, HTL 1071, AZD-4635)

生物&药学活性

物理化学性质&存储条件

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