AZD3778 | Dual CCR3/H1 antagonist | Probechem Biochemicals

Chemical Structure : AZD3778

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AZD3778 (AZD-3778, AZD 3778)

货号: PC-20729Not For Human Use, Lab Use Only.

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生物&药学活性

AZD3778 (AZD-3778) is a dual CCR3 and H1-receptor antagonistwith Ki of 54 nM for guinea-pig H1-receptor, inhibits binding of CR3 radioligand 125I-eotaxin to human CCR3-receptor expressed on CHO-cells with IC50 of 8 nM.
AZD3778 inhibits chemotaxis of eosinophils.
AZD3778 also inhibits the binding of a specific H1-radioligand, 3H-pyrilamin, to the human H1-receptor expressed on CHO-cells with an IC50 of 40 nM.
AZD3778 inhibits histamine-induced calcium flux with an IC50 of 63 nM in human HeLa-cells expressing the human H1-receptor.
AZD3778 affects allergic inflammation and symptoms in allergic rhinitis.

物理化学性质&存储条件

分子量	526.47
分子式	C24H29Cl2N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N1CCC(N2CCC(OC3=CC=C(Cl)C(Cl)=C3)CC2)CC1)NS(=O)(C4=CC=C(C)C=C4)=O

参考文献

1. Lennart Greiff , et al. Respir Res. 2010 Feb 9;11(1):17.

AZD3778 (AZD-3778, AZD 3778)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZD3778 (AZD-3778, AZD 3778)

生物&药学活性

物理化学性质&存储条件

参考文献

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