AZD3458 (AZD-3458)

Chemical Structure : AZD3458

CAS No.: 2132961-46-5

加入收藏

货号: PC-28807Not For Human Use, Lab Use Only.

AZD3458 (AZD-3458) is a potent and remarkably selective PI3Kγ inhibitor with pIC50 of 9.1, displays >100-fold selectivity over PI3Kα/β/δ.

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2780	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AZD3458 (AZD-3458) is a potent and remarkably selective PI3Kγ inhibitor with pIC50 of 9.1, displays >100-fold selectivity over PI3Kα/β/δ.
AZD3458 exhibits PI3Kγ target engagement cell assay measuring phosphorylation of AKT with pIC50 of 8.1.
AZD3458 enhanced antitumor activity of immune checkpoint inhibitors in 4T1, CT26, and MC38 syngeneic models, increasing CD8+ T-cell activation status.
AZD3458 alone or in combination with PD-1-blocking antibodies promoted an increase in antigen-presenting (MHCII+) and cytotoxic (iNOS+)-activated macrophages, as well as dendritic cell activation.
AZD3458 reduced IL-10 secretion and signaling in primary human macrophages and murine tumor-associated macrophages, but did not strongly regulate IL-12.
AZD3458 shows dose-dependent inhibition of LPS-induced airway neutrophilia in rats.

物理化学性质&存储条件

分子量	433.54
分子式	C20H23N3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(5-(2-(1-Cyclopropylethyl)-7-(methylsulfonyl)-1-oxoisoindolin-5-yl)-4-methylthiazol-2-yl)acetamide

参考文献

1. Carnevalli LS, et al. Mol Cancer Ther. 2021 Jun;20(6):1080-1091.

2. Pemberton N, et al. J Med Chem. 2018 Jun 28;61(12):5435-5441.

AZD3458 (AZD-3458)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AZD3458 (AZD-3458)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.