AZD3043 |CAS:579494-66-9 Probechem Biochemicals

Chemical Structure : AZD3043

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AZD3043 (THRX-918661, AZD-3043, THRX918661)

货号: PC-63159Not For Human Use, Lab Use Only.

AZD 3043 (THRX-918661) is a positive allosteric modulator of the GABAA receptor in vitro and a sedative/hypnotic agent in vivo, potentiates GABAA receptor-mediated chloride currents with EC50 of 36 uM.

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生物&药学活性

AZD 3043 (THRX-918661) is a positive allosteric modulator of the GABAA receptor in vitro and a sedative/hypnotic agent in vivo, potentiates GABAA receptor-mediated chloride currents with EC50 of 36 uM.
AZD3043 potentiates and directly activates the α1β2γ2, α2β2γ2 and α2β3γ2 GABA(A) receptor subtypes, produces hypnosis and electroencephalograph depression in rats.

物理化学性质&存储条件

分子量	351.443
分子式	C19H29NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[4-[(N,N-Diethylcarbamoyl)methoxy]-3-ethoxyphenyl]acetic acid propyl ester

参考文献

1. Egan TD, et al. Anesthesiology. 2012 Jun;116(6):1267-77.

2. Jonsson Fagerlund M, et al. Eur J Pharmacol. 2012 Nov 5;694(1-3):13-9.

3. Björnsson MA, et al. Anesth Analg. 2015 Oct;121(4):904-13.

AZD3043 (THRX-918661, AZD-3043, THRX918661)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZD3043 (THRX-918661, AZD-3043, THRX918661)

生物&药学活性

物理化学性质&存储条件

参考文献

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