AZD2098 (AZD-2098) | CCR4 antagonist | Probechem Biochemicals

Chemical Structure : AZD2098

CAS No.: 566203-88-1

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AZD2098 (AZD 2098, AZD-2098)

货号: PC-61687Not For Human Use, Lab Use Only.

AZD2098 (AZD-2098) is a potent, selective, orally bioavailable CCR4 receptor antagonist with pIC50 of 7.8 for hCCR4, pIC50 of 8.0 for rCCR4.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

AZD2098 (AZD-2098) is a potent, selective, orally bioavailable CCR4 receptor antagonist with pIC50 of 7.8 for hCCR4, pIC50 of 8.0 for rCCR4.
AZD2098 shows no significant activity against a panel of chemokine receptors (CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, CCR8; inactive at 10 uM).
AZD2098 inhibits Th2 cell CCL22 driven chemotaxis in 0.3% HSA with pIC50 of 6.3.
AZD2098 exhibits anti-inflammatory effects in Brown-Norway rats sensitized to ovalbumin.

物理化学性质&存储条件

分子量	334.171
分子式	C11H9Cl2N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide

参考文献

1. Kindon N, et al. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986.

AZD2098 (AZD 2098, AZD-2098)

生物&药学活性

物理化学性质&存储条件

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AZD2098 (AZD 2098, AZD-2098)

生物&药学活性

物理化学性质&存储条件

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