AZD2066 | mGluR5 antagonist | Probechem Biochemicals

Chemical Structure : AZD2066

CAS No.: 934282-55-0

加入收藏

AZD2066 (AZD-2066)

货号: PC-60791Not For Human Use, Lab Use Only.

AZD2066 is a potent, selective, highly CNS-penetrant mGluR5 antagonist, inhibits Ca2+ response in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures with IC50 of 27.2, 3.56, 96.2, and 380 nM respectively.

规格	价格	库存
5 mg	￥3880	In stock
10 mg	￥5780	In stock
25 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AZD2066 is a potent, selective, highly CNS-penetrant mGluR5 antagonist, inhibits Ca2+ response in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures with IC50 of 27.2, 3.56, 96.2, and 380 nM respectively.
AZD2066 inhibits transient lower oesophageal sphincter relaxations (TLESRs) in animals and acid reflux, shows potential for treatment of gastro-oesophageal reflux.

物理化学性质&存储条件

分子量	381.82
分子式	C19H16ClN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridine

参考文献

1. Rohof WO, et al. Aliment Pharmacol Ther. 2012 May;35(10):1231-42.

2. Nordmark A, et al. Eur J Clin Pharmacol. 2014 Feb;70(2):167-78.

3. Swedberg MD, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):212-22.

AZD2066 (AZD-2066)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AZD2066 (AZD-2066)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.