AZD 1678 |CAS:942137-41-9 Probechem Biochemicals

Chemical Structure : AZD 1678

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AZD 1678 (AZD1678;AZD-1678)

货号: PC-61688Not For Human Use, Lab Use Only.

AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4.

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生物&药学活性

AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4.
CCR4 shows no significant activity against a panel of chemokine receptors (CXCR1, CXCR2, CCR1, CCR2b, CCR5, CCR7, CCR8; inactive at 10 uM).
CCR4 inhibits Th2 cell CCL22 driven chemotaxis in 0.3% HSA with pIC50 of 6.8.

物理化学性质&存储条件

分子量	352.1614
分子式	C11H8Cl2FN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3-Dichloro-N-(5-fluoro-3-methoxy-2-pyrazinyl)benzenesulfonamide

参考文献

1. Kindon N, et al. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986.

AZD 1678 (AZD1678;AZD-1678)

生物&药学活性

物理化学性质&存储条件

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AZD 1678 (AZD1678;AZD-1678)

生物&药学活性

物理化学性质&存储条件

参考文献

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