AZD1390 | ATM inhibitor | Probechem Biochemicals

Chemical Structure : AZD1390

CAS No.: 2089288-03-7

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AZD1390 (AZD 1390, AZD-1390)

货号: PC-61826Not For Human Use, Lab Use Only.

AZD1390 (AZD-1390) is a novel potent, selective, orally available and CNS penetrant ATM inhibitor with IC50 of 0.78 nM, displays >1,000-fold selectivity over closely related (PIKKs) and distant kinases.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥2980	In stock
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100 mg		Get quote

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生物&药学活性

AZD1390 (AZD-1390) is a novel potent, selective, orally available and CNS penetrant ATM inhibitor with IC50 of 0.78 nM, displays >1,000-fold selectivity over closely related (PIKKs) and distant kinases.
AZD1390 radiosensitises a panel of glioblastoma multiforme (GBM) cell lines and NCI-H2228 lung cells (IC50=3 nM).
AZD1390 demonstrates potential in combination with radiation therapy for the treatment of brain tumors.

物理化学性质&存储条件

分子量	477.584
分子式	C27H32FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Imidazo[4,5-c]quinolin-2-one,7-fluoro-1,3-dihydro-3-methyl-1-(1-methylethyl)-8-[6-[3-(1-piperidinyl)propoxy]-3-pyridinyl]-

参考文献

1. Kurt G. Pike. Abstract A124: Discovery of the clinical candidate AZD1390: a high-quality, potent, and selective inhibitor of ATM kinase with the ability to cross the blood-brain barrier. AACR. DOI: 10.1158/1535-7163.

AZD1390 (AZD 1390, AZD-1390)

生物&药学活性

物理化学性质&存储条件

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AZD1390 (AZD 1390, AZD-1390)

生物&药学活性

物理化学性质&存储条件

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