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首页-小分子抑制剂&激动剂-GPCR-P2Y Receptor-AZD1283
AZD1283

Chemical Structure : AZD1283

CAS No.: 919351-41-0

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AZD1283 (AZD-1283, AZD 1283)

货号: PC-20648Not For Human Use, Lab Use Only.

AZD1283 (AZD-1283) is a potent, selective P2Y12 receptor antagonist with binding IC50 of 11 nM, and IC50 of 3.2 uM in washed platelet assay (WPA).

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD1283 (AZD-1283) is a potent, selective P2Y12 receptor antagonist with binding IC50 of 11 nM, and IC50 of 3.2 uM in washed platelet assay (WPA).
AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 μg/kg/min.

物理化学性质&存储条件

分子量 470.54
分子式 C23H26N4O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate

参考文献

1. Kong D, et al. J Med Chem. 2019 Mar 28;62(6):3088-3106.

2. Bach P, et al. J Med Chem. 2013 Sep 12;56(17):7015-24.

3. Zhang K, et al. Nature. 2014 May 1;509(7498):115-8.

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