AZD1208 | Pim inhibitor | Probechem Biochemicals

Chemical Structure : AZD1208

CAS No.: 1204144-28-4

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AZD1208 (AZD-1208)

货号: PC-22796Not For Human Use, Lab Use Only.

AZD1208 is a potent and selective, ATP-competitive pan-Pim kinase inhibitor with IC50 of 0.4/5.0/1.9 nM for Pim-1/2/3, respectively.

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10 mg	￥780	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg	￥3680	In stock
250 mg		Get quote

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生物&药学活性

AZD1208 is a potent and selective, ATP-competitive pan-Pim kinase inhibitor with IC50 of 0.4/5.0/1.9 nM for Pim-1/2/3, respectively.
AZD1208 has Ki values of 0.1 nM for Pim-1, 1.92 nM for Pim-2, and 0.4 nM for Pim-3.
AZD1208 inhibits AML cell-line growth and can induce cell-cycle arrest and apoptosis, accompanied by a dose-dependent reduction in phosphorylation of Bcl-2 antagonist of cell death, 4EBP1, p70S6K, and S6.
AZD1208 potently inhibits the level of pBAD with IC50 of 10 nM for Pim-1, 151 nM for Pim-2, and 102 nM for Pim-3in U2-OS cells.
AZD1208 (10 mg/kg or 30 mg/kg) inhibits the growth of MOLM-16 and KG-1a xenograft tumors in vivo.

物理化学性质&存储条件

分子量	379.48
分子式	C21H21N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dione

参考文献

1. Keeton EK,

2. Dakin LA, et al. Bioorg Med Chem Lett. 2012;22(14):4599–4604.

AZD1208 (AZD-1208)

生物&药学活性

物理化学性质&存储条件

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AZD1208 (AZD-1208)

生物&药学活性

物理化学性质&存储条件

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