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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Glucokinase-AZD1092
AZD1092

Chemical Structure : AZD1092

CAS No.: 871656-65-4

AZD1092 (GKA-80, AZ1092, GKA80)

货号: PC-61877Not For Human Use, Lab Use Only.

AZD1092 (GKA-80) is a potent Glucokinase (GK) activator with EC50 of 30 nM.

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25 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AZD1092 (GKA-80) is a potent Glucokinase (GK) activator with EC50 of 30 nM.
    AZD1092 exhibits dose dependent reduction of glucose excursion in oral glucose tolerance tests in high fat fed female Zucker rats.
    AZD1092 shows potential for treatment of type 2 diabetes.

    物理化学性质&存储条件

    分子量 450.495
    分子式 C24H26N4O5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-[4-(1-Azetidinylcarbonyl)phenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

    参考文献

    1. Coope GJ, et al. Br J Pharmacol. 2006 Oct;149(3):328-35.

    2. Michael J. Waring, et al. Med. Chem. Commun., 2011, 2, 775-779

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