AZD0449 | JAK1 inhibitor | Probechem Biochemicals

Chemical Structure : AZD0449

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AZD0449 (AZD-0449)

货号: PC-49307Not For Human Use, Lab Use Only.

AZD0449 (AZD-0449) is a potent and highly selective JAK1 inhibitor with IC50 of 2.4 nM, displays >50-fold selectivity over TYK2 and JAK2, and no inhibition against JAK3.

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生物&药学活性

AZD0449 (AZD-0449) is a potent and highly selective JAK1 inhibitor with IC50 of 2.4 nM, displays >50-fold selectivity over TYK2 and JAK2, and no inhibition against JAK3.
AZD0449 inhibited JAK1-dependent signaling, determined by reductions in IL-4-induced STAT6 phosphorylation in human CD4+ T cells with IC50 of 21.4 nM, inhibited IL-13-induced phosphorylation of STAT6- and TSLP-induced production of CCL17.
AZD0449 dose-dependently inhibited STAT3, STAT5a, and STAT5b phosphorylation in lung tissue from ovalbumin (OVA)-challenged rats.
AZD0449 also inhibited eosinophilia in the lung and reduced the late asthmatic response, measured as Penh in the OVA rat model.

物理化学性质&存储条件

分子量	375.432
分子式	C21H21N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-methyl-2-((3,4,5-trimethylphenyl)amino)pyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one

参考文献

1. Magnus Nilsson, et al. Drug Des Devel Ther. 2022 Aug 31;16:2901-2917.

AZD0449 (AZD-0449)

生物&药学活性

物理化学性质&存储条件

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AZD0449 (AZD-0449)

生物&药学活性

物理化学性质&存储条件

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