AZD0424 |CAS:692054-06-1 Probechem Biochemicals

Chemical Structure : AZD0424

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AZD0424 (AZD-0424, AZD 0424)

货号: PC-62498Not For Human Use, Lab Use Only.

AZD 0424 is an orally bioavailable small molecule tyrosine kinase inhibitor of Abl and Src kinase with potential antineoplastic activity..

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

AZD0424 is an orally bioavailable small molecule tyrosine kinase inhibitor of Abl and Src kinase, potently inhibits the phosphorylation of Tyr419 of SRC with IC50 of 100 nM in cancer cell lines.
AZD0424 induces apoptosis and mediate cell cycle arrest in lymphoma cells.
SRC is activated in response to treatment of KRAS-mutant colorectal cell lines with MEK inhibitors (trametinib or AZD6244) and that AZD0424 abrogates this.

物理化学性质&存储条件

分子量	528.994
分子式	C25H29ClN6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(2-((4-((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino)-5-isopropoxyquinazolin-7-yl)oxy)ethyl)piperazin-1-yl)ethan-1-one

参考文献

1. Woodcock VK, et al. Br J Cancer. 2018 Feb 13. doi: 10.1038/bjc.2017.484.

2. Nowak D, et al. Anticancer Drugs. 2007 Oct;18(9):981-95.

AZD0424 (AZD-0424, AZD 0424)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZD0424 (AZD-0424, AZD 0424)

生物&药学活性

物理化学性质&存储条件

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