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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Arginase-AZD0011-PL
AZD0011-PL

Chemical Structure : AZD0011-PL

CAS No.: 2374807-39-1

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AZD0011-PL (AZD 0011-PL)

货号: PC-20188Not For Human Use, Lab Use Only.

AZD0011-PL is a highly potent Arginase (ARG) inhibitor with IC50 of 7/15 nM for ARG1/2, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AZD0011-PL is a highly potent Arginase (ARG) inhibitor with IC50 of 7/15 nM for ARG1/2, respectively.
    AZD0011-PL only inhibits extracellular ARG available in TME or periphery, fully restores T cell proliferation.
    AZD0011-PL is the bioactive form of AZD0011.

    物理化学性质&存储条件

    分子量 230.07
    分子式 C9H19BN2O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2R,4R)-4-amino-2-(4-boronobutyl)pyrrolidine-2-carboxylic acid

    参考文献

    1. Doshi AS, et al. Mol Cancer Ther. 2023 Mar 13:MCT-22-0431.

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