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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-P2X Receptor-AZD-9056 hydrochloride
AZD-9056 hydrochloride

Chemical Structure : AZD-9056 hydrochloride

CAS No.: 345303-91-5

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AZD-9056 hydrochloride (AZD9056 hydrochloride)

货号: PC-45634Not For Human Use, Lab Use Only.

AZD-9056 hydrochloride is a potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM.

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10 mg ￥2280 In stock
25 mg ￥3880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD-9056 hydrochloride is a potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM.
AZD-9056 hydrochloride displays >100-fold selectivity and specificity other P2X receptors.
AZD-9056 hydrochloride also is an inhibitor of BCRP and weakly inhibited BCRP-mediated transport of methotrexate (IC50=92 uM).
AZD-9056 hydrochloride significantly reduces disease severity in the streptococcal cell wall (SCW) model of arthritis.

物理化学性质&存储条件

分子量 455.46084
分子式 C24H36Cl2N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 34 mg/mL
Chemical Name/SMILES

Benzamide, 2-chloro-5-[3-[(3-hydroxypropyl)amino]propyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-, hydrochloride (1:1)

参考文献

1. Hu H, et al. Int J Mol Med. 2016 Dec;38(6):1922-1932.

2. Seeland S, et al. Int J Mol Med. 2016 Dec;38(6):1922-1932.

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