AZD-9056 |CAS:345304-65-6 Probechem Biochemicals

Chemical Structure : AZD-9056

CAS No.: 345304-65-6

加入收藏

AZD-9056 (AZD9056, AZD 9056)

货号: PC-70094Not For Human Use, Lab Use Only.

AZD-9056 is a potent, selective, orally bioavailable P2X7 receptor antagonist, inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AZD-9056 is a potent, selective, orally bioavailable P2X7 receptor antagonist, inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM.
AZD-9056 displays >100-fold selectivity and specificity other P2X receptors.
AZD-9056 also is an inhibitor of BCRP and weakly inhibited BCRP-mediated transport of methotrexate (IC50=92 uM).
AZD-9056 significantly reduces disease severity in the streptococcal cell wall (SCW) model of arthritis.

物理化学性质&存储条件

分子量	419.006
分子式	C24H35ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(adamantan-1-ylmethyl)-2-chloro-5-(3-((3-hydroxypropyl)amino)propyl)benzamide

参考文献

1. Hu H, et al. Int J Mol Med. 2016 Dec;38(6):1922-1932.

2. Seeland S, et al. Int J Mol Med. 2016 Dec;38(6):1922-1932.

AZD-9056 (AZD9056, AZD 9056)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AZD-9056 (AZD9056, AZD 9056)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.