AZD-7624 |CAS:1095004-78-6 Probechem Biochemicals

Chemical Structure : AZD-7624

CAS No.: 1095004-78-6

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AZD-7624 (AZD7624)

货号: PC-63284Not For Human Use, Lab Use Only.

AZD-7624 (AZD7624) is a potent, selective, inhaled p38α MAPK inhibitor with pIC50 of 10.0, displays 15-fold selectivity for p38α over p38β MAPK and >10,000-fold selectivity over p38γ and p38δ MAPK.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4680	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AZD-7624 (AZD7624) is a potent, selective, inhaled p38α MAPK inhibitor with pIC50 of 10.0, displays 15-fold selectivity for p38α over p38β MAPK and >10,000-fold selectivity over p38γ and p38δ MAPK.
AZD-7624 inhibits LPS-induced TNF-α and IL-6 release in human alveolar macrophages pIC50 of 9.2 and 8.8, respectively。
AZD-7624 shows potential for prevention of exacerbations in COPD.

物理化学性质&存储条件

分子量	491.56
分子式	C27H30FN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-cyclopropyl-3-fluoro-4-methyl-5-(3-((1-(2-(2-(methylamino)ethoxy)phenyl)cyclopropyl)amino)-2-oxopyrazin-1(2H)-yl)benzamide

参考文献

1. Patel NR, et al. Int J Chron Obstruct Pulmon Dis. 2018 Mar 27;13:1009-1019.

2. Pehrson R, et al. J Pharmacol Exp Ther. 2018 Mar 16. pii: jpet.117.246132.

AZD-7624 (AZD7624)

生物&药学活性

物理化学性质&存储条件

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AZD-7624 (AZD7624)

生物&药学活性

物理化学性质&存储条件

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