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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Glucocorticoid receptor (GR)-AZD-5423
AZD-5423

Chemical Structure : AZD-5423

CAS No.: 1034148-04-3

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AZD-5423 (AZD5423)

货号: PC-20260Not For Human Use, Lab Use Only.

AZD-5423 (AZD5423) is a potent, nonsteroidal, selective glucocorticoid receptor modulator with IC50 of 49 pM for inhibition of AP-1 mediated transcription.

规格 价格 库存 数量
10 mg ￥980 In stock
25 mg ￥1780 In stock
50 mg ￥2880 In stock
100 mg ￥4880 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZD-5423 (AZD5423) is a potent, nonsteroidal, selective glucocorticoid receptor modulator with IC50 of 49 pM for inhibition of AP-1 mediated transcription.
AZD-5423 displays a potent inhibition of lung edema in a rat model of allergic airway inflammation following dry powder inhalation combined with a moderate systemic GR-effect.
AZD5423 also is potent RIPK3 inhibitor, strongly inhibits activation of RIPK3, and MLKL phosphorylation upon cisplatin-, hypoxia/reoxygenation (H/R)- and TNF-α stimuli as compared with GSK872.
AZD5423 exerts effective protection against cisplatin- and ischemia/reperfusion (I/R)-induced AKI mouse model.

物理化学性质&存储条件

分子量 487.45
分子式 C25H21F4N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)propan-2-yl)acetamide

参考文献

1. Gauvreau GM, et al. Am J Respir Crit Care Med. 2015 Jan 15;191(2):161-7.

2. Werkström V, et al. Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):574-581.

3. Hemmerling M, et al. J Med Chem. 2017 Oct 26;60(20):8591-8605.

4. Xu CH, et al. Int Immunopharmacol. 2022 Nov;112:109262.

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