AZD-4818 |CAS:1003566-93-5 Probechem Biochemicals

Chemical Structure : AZD-4818

CAS No.: 1003566-93-5

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AZD-4818 (AZD4818)

货号: PC-62762Not For Human Use, Lab Use Only.

AZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner.

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10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4580	In stock
100 mg	￥7580	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

AZD-4818 is a highly potent, selective CCR1 antagonist with pIC50 of 8.6, inhibits chemotaxia of human monocytes to MIP-1α in a concentration-dependent manner.
AZD-4818 significantly reduces neutrophil influx and TNF-α levels on bronchoalveolar lavage (BAL) following intratracheal administration in vivo.

物理化学性质&存储条件

分子量	567.46
分子式	C27H32Cl2N2O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[2-Chloro-5-[(2S)-3-(5-chlorospiro[benzofuran-2(3H),4'-piperidin]-1'-yl)-2-hydroxypropoxy]-4-[(methylamino)carbonyl]phenoxy]-2-methylpropanoic acid

参考文献

1. Kerstjens HA, et al. Respir Med. 2010 Sep;104(9):1297-303.

2. Norman P. Expert Opin Ther Pat. 2009 Nov;19(11):1629-33.

3. Gilchrist A, et al. Br J Pharmacol. 2014 Nov;171(22):5127-38.

AZD-4818 (AZD4818)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZD-4818 (AZD4818)

生物&药学活性

物理化学性质&存储条件

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