AZD-1480 | JAK2 inhibitor | Probechem Biochemicals

Chemical Structure : AZD-1480

CAS No.: 935666-88-9

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AZD-1480 (AZD1480;AZD 1480)

货号: PC-42438Not For Human Use, Lab Use Only.

AZD-1480 (AZD1480) is a potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM.

规格	价格	库存
1 mg (Free Sample)	￥280	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3380	In stock
100 mg		Get quote

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生物&药学活性

AZD-1480 (AZD1480) is a potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM.
AZD-1480 demonstrates significant JAK2 selectivity over JAK3 and marginal selectivity over JAK1.
AZD-1480 blocks STAT3 phosphorylation in a panel of human solid tumor cell lines, potently inhibits the growth of the TEL-Jak2 cell line (GI50=60 nM).
AZD-1480 suppresses the growth of human solid tumor xenografts harboring persistent Stat3 activity.

物理化学性质&存储条件

分子量	348.766
分子式	C14H14ClFN8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Pyrimidinediamine, 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-

参考文献

1. Hedvat M, et al. Cancer Cell. 2009 Dec 8;16(6):487-97.

2. Ioannidis S, et al. J Med Chem. 2011 Jan 13;54(1):262-76.

3. Scuto A, et al. Leukemia. 2011 Mar;25(3):538-50.

4. Xin H, et al. Cancer Res. 2011 Nov 1;71(21):6601-10.

AZD-1480 (AZD1480;AZD 1480)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZD-1480 (AZD1480;AZD 1480)

生物&药学活性

物理化学性质&存储条件

参考文献

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