AZD-0865 |CAS:248919-64-4 Probechem Biochemicals

Chemical Structure : AZD-0865

CAS No.: 248919-64-4

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AZD-0865 (Linaprazan;AZD0865;AZD 0865)

货号: PC-42143Not For Human Use, Lab Use Only.

A potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 6.5.

规格	价格	库存
5 mg	￥2800	In stock
10 mg	￥4000	In stock
50 mg	￥12000	In stock
100 mg	￥16800	In stock

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生物&药学活性

A potent, selective acid pump antagonist (potassium-competitive acid blocker or P-CAB) that reversiblely inhibits gastric H+/K+-ATPase with pIC50 of 6.5; inhibits H+/K+-ATPase activity in a K(+)-competitive manner with Ki of 46 nM, shows no ativity for porcine renal Na(+),K(+)-ATPase at 100 uM; inhibits gastric acid secretion in vivo.

Ulcer

Phase 2 Discontinued

物理化学性质&存储条件

分子量	366.4567
分子式	C21H26N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 35 mg/mL
Chemical Name/SMILES	Imidazo[1,2-a]pyridine-6-carboxamide, 8-[[(2,6-dimethylphenyl)methyl]amino]-N-(2-hydroxyethyl)-2,3-dimethyl-

参考文献

1. Bailey N, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3602-6.

2. Gedda K, et al. Biochem Pharmacol. 2007 Jan 15;73(2):198-205.

3. Kirchhoff P, et al. Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G838-43.

AZD-0865 (Linaprazan;AZD0865;AZD 0865)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZD-0865 (Linaprazan;AZD0865;AZD 0865)

生物&药学活性

物理化学性质&存储条件

参考文献

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