AZ960 | JAK2 inhibitor | Probechem Biochemicals

Chemical Structure : AZ960

CAS No.: 905586-69-8

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AZ960 (AZ-960;AZ 960)

货号: PC-42571Not For Human Use, Lab Use Only.

AZ960 is a potent, selective JAK2 inhibitor with Ki of 0.45 nM, IC50 of <3 nM.

规格	价格	库存
1 mg (Free Sample)	￥280	In stock
5 mg	￥1480	In stock
10 mg	￥2380	In stock
25 mg	￥3880	In stock
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100 mg		Get quote

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生物&药学活性

AZ960 is a potent, selective JAK2 inhibitor with Ki of 0.45 nM, IC50 of <3 nM.
AZ960 displays 3-fold selectivity over JAK3 (IC50=9 nM).
AZ960 blocks STAT5 phosphorylation and potently inhibits cell proliferation (GI50=25 nM) in TEL-JAK2 driven Ba/F3 cells, blocks BCL-XL, PIM1 and PIM2 mRNA expression and induces apoptosis; also induces growth arrest and apoptosis in adult T-cell leukemia cells.
AZ960 also inhibits parasite Trypanosoma brucei ERK8 (Ki=1.25 uM) with antiparasitic activity (IC50=120nM).

物理化学性质&存储条件

分子量	354.3566464
分子式	C18H16F2N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-

参考文献

1. Gozgit JM, et al. J Biol Chem. 2008 Nov 21;283(47):32334-43.

2. Yang J, et al. Mol Cancer Ther. 2010 Dec;9(12):3386-95.

3. Valenciano AL, et al. Bioorg Med Chem. 2016 Oct 1;24(19):4647-4651.

AZ960 (AZ-960;AZ 960)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZ960 (AZ-960;AZ 960)

生物&药学活性

物理化学性质&存储条件

参考文献

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