AZ9567 | MAT2A inhibitor | Probechem Biochemicals

Chemical Structure : AZ9567

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AZ9567 (AZ'9567, AZ 9567)

货号: PC-21926Not For Human Use, Lab Use Only.

AZ9567 is a potent, selective methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 1 nM, selectively targets MTAP-deficient cancer cells.

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生物&药学活性

AZ9567 is a potent, selective methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 1 nM, selectively targets MTAP-deficient cancer cells.
AZ9567 demonstrates potent cellular inhibition of MAT2a-driven SAM synthesis in the engineered HCT116 MTAP knockout (KO) model with pIC50 of 8.6.
AZ9567 displays preferential sensitivity in MTAP KO HCT116 compared to isogenic parental HCT116 for SDMA and growth inhibition.
AZ9567 exhibits selective antiproliferative activity toward MTAP-null lymphoma, lung, and pancreatic cancer cell lines.
AZ9567 (20 mg/kg BID) shows robust antitumor response in MTAP KO HCT116 xenograft model.

物理化学性质&存储条件

分子量	447.45
分子式	C24H19F2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Cyclopropyl-4-(4-(difluoromethoxy)phenyl)-6-(2-methyl-2H-indazol-5-yl)-1,4-dihydro-5H-pyrazolo[4,3-b]pyridin-5-one

参考文献

1. Atkinson SJ, et al. J Med Chem. 2024 Mar 11. doi: 10.1021/acs.jmedchem.3c01860.

AZ9567 (AZ'9567, AZ 9567)

生物&药学活性

物理化学性质&存储条件

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AZ9567 (AZ'9567, AZ 9567)

生物&药学活性

物理化学性质&存储条件

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