AZ876 | LXR agonist | Probechem Biochemicals

Chemical Structure : AZ876

CAS No.: 898800-26-5

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AZ876 (AZ-876, AZ 876)

货号: PC-45444Not For Human Use, Lab Use Only.

AZ876 (AZ 876) is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

AZ876 (AZ 876) is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
AZ876 is a more potent binder and activator of LXRα and LXRβ than GW3965.
AZ876 is highly selective against FXR, RXR, TRα, TRβ etc.
AZ876 reduces lesion area, and strongly decreases lesion area, lesion number and severity in vivo.
AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects in mice.

物理化学性质&存储条件

分子量	439.5704
分子式	C24H29N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 2.6 mg/mL
Chemical Name/SMILES	3(2H)-Isothiazolone, 2-(1,1-dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl]amino]-, 1,1-dioxide

参考文献

1. van der Hoorn J, et al. Br J Pharmacol. 2011 Apr;162(7):1553-63.

2. Cannon MV, et al. Eur J Heart Fail. 2015 Mar;17(3):273-82.

AZ876 (AZ-876, AZ 876)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZ876 (AZ-876, AZ 876)

生物&药学活性

物理化学性质&存储条件

参考文献

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