AZ82 | KIFC1 inhibitor | Probechem Biochemicals

Chemical Structure : AZ82

CAS No.: 1449578-65-7

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AZ82 (KIFC1 inhibitor AZ82)

货号: PC-62374Not For Human Use, Lab Use Only.

AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor of motor protein KIFC1 that inhibits the MT-stimulated KIFC1 enzymatic activity in an ATP-competitive and MT-noncompetitive manner with Ki of 43 nM.

规格	价格	库存
5 mg	￥2280	In stock
10 mg	￥3780	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor of motor protein KIFC1 that inhibits the MT-stimulated KIFC1 enzymatic activity in an ATP-competitive and MT-noncompetitive manner with Ki of 43 nM.
AZ82 effectively engages with the minus end-directed KIFC1 motor inside cells to reverse the monopolar spindle phenotype induced by the inhibition of the plus end-directed kinesin Eg5.
AZ82 causes centrosome declustering in BT-549 breast cancer cells with amplified centrosomes.

物理化学性质&存储条件

分子量	560.6
分子式	C28H31F3N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-methyl-N-((R)-1-oxo-1-(((R)-pyrrolidin-3-yl)amino)-3-(6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-2-yl)-4-propylthiophene-2-carboxamide

参考文献

1. Wu J, et al. ACS Chem Biol. 2013 Oct 18;8(10):2201-8.

2. Yang B, et al. J Med Chem. 2014 Dec 11;57(23):9958-70.

AZ82 (KIFC1 inhibitor AZ82)

生物&药学活性

物理化学性质&存储条件

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AZ82 (KIFC1 inhibitor AZ82)

生物&药学活性

物理化学性质&存储条件

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